File:Gram-negative-TRPV4response.jpg

Summary[edit | edit source]

Gram-negative bacteria leading to LPS response and TRPV4 channel activation.

Description: Acute responses in epithelial cells after activation of TRPV4 by LPS. LPS shed by gram-negative bacteria during colonization near the epithelial surface activates TRPV4 channels expressed in ciliated epithelial cells, leading to a Ca2+ influx that triggers acute cellular responses such as the production of bactericidal nitric oxide and increased ciliary beat frequency. NO, nitric oxide; CBF, ciliary beat frequency.

Author: Boonen et al (2018. Citation: Toxins 2018, 10(8), 326; https://doi.org/10.3390/toxins10080326 Source: TRP Channels as Sensors of Bacterial Endotoxins Fig 3 https://www.mdpi.com/2072-6651/10/8/326

Licensing[edit | edit source]

	This file is licensed under the Creative Commons Attribution 4.0 International license.
	You are free: to share – to copy, distribute and transmit the work to remix – to adapt the work Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. https://creativecommons.org/licenses/by/4.0 CC BY 4.0 Creative Commons Attribution 4.0 truetrue