File:ImmuneOxidativeStressModelData2021.png

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Title: (or description)[edit | edit source]

Immune and oxidative stress disorder model of ME/CFS. Immune-mediated and neuro Results of cluster analysis performed on latent variable (LV) scores reflecting causome, protectome, adverse outcome pathways and phenome data.

Author: (or citation)[edit | edit source]

Maes, M.; Kubera, M.; Stoyanova, K.; Leunis, J. The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups. Preprints 2021, 2021010623.
Figure 4.

Source: (e.g. internet address)[edit | edit source]

https://www.preprints.org/manuscript/202101.0623/v1

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myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

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current21:50, February 12, 2021Thumbnail for version as of 21:50, February 12, 2021850 × 501 (35 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== '''Immune and oxidative stress disorder model of ME/CFS'''. Immune-mediated and neuro Results of cluster analysis performed on latent variable (LV) scores reflecting causome, protectome, adverse outcome pathways a...

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