GETSET trial

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The GETSET trial (short for Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome) was a trial investigating the effectiveness of "guided graded exercise self-help" in patients with CFS/ME. The protocol was published in June 2016.[1] The results were published in June 2017.[2]

Researchers[edit | edit source]

Lead Author Lucy Clark, Peter White, Francesca Pesola, Janice M Thomas, Mario Vergara-Williamson and Michelle Beynon

Funding[edit | edit source]

The trial was funded in full by the National Institute for Health Research's Research for Patient Benefit programme.[3]

Protocol[edit | edit source]

The protocol of the trial was published in JMIR Research Protocols in June 2016.[1]

Publication[edit | edit source]

The results were published on 22 June 2017 in the Lancet: Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial[4]

Commentary was provided by Daniel Clauw in the Lancet: Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome.[5]

The Science Media Centre provided: Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS).[6]

It was reported in the Telegraph as Exercise can help chronic fatigue syndrome, study shows and other media outlets: Defeating chronic fatigue thanks to guided self-help approach to exercise.[7]

Criticism[edit | edit source]

Dr David Tuller has criticized the trial Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet.

Spoonseekerdotcom has criticised the GETSET trial.[8][9][10]

Professor Jonathan Edwards criticised the study for its "incompetent level of science".[11]

The ME Association has also criticised the trial ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function.

Additional criticism has been published by other patients [12][13].

Documents[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.01.1 Clark, Lucy V.; McCrone, Paul; Ridge, Damien; Cheshire, Anna; Vergara-Williamson, Mario; Pesola, Francesca; White, Peter D. (Jun 8, 2016), "Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study", JMIR research protocols, 5 (2): 70, doi:10.2196/resprot.5395, PMC 4917732Freely accessible, PMID 27278762 
  2. Clark, Lucy V.; Pesola, Francesca; Thomas, Janice; Vergara-Williamson, Mario; Beynon, Michelle; White, Peter D. (Jun 22, 2017), "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial", The Lancet, doi:10.1016/S0140-6736(16)32589-2 
  3. "ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME". www.isrctn.com. Retrieved Jan 26, 2020. 
  4. Clark, Lucy V.; Pesola, Francesca; Thomas, Janice M.; Vergara-Williamson, Mario; Beynon, Michelle; White, Peter D. (Jul 22, 2017). "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial". The Lancet. 390 (10092): 363–373. doi:10.1016/S0140-6736(16)32589-2. ISSN 0140-6736. PMID 28648402. 
  5. Clauw, Daniel J (Jul 2017). "Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome". The Lancet. 390 (10092): 335–336. doi:10.1016/S0140-6736(17)30577-9. 
  6. "expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) | Science Media Centre". Retrieved May 8, 2020. 
  7. "Defeating chronic fatigue thanks to guided self-help approach to exercise". Emergency Live. Retrieved May 8, 2020. 
  8. Spoonseeker, Author (May 23, 2016). "A Few Notes on GETSET". spoonseekerdotcom. Retrieved Jan 26, 2020. 
  9. Spoonseeker, Author (Jun 29, 2017). "Do GET Yourself". spoonseekerdotcom. Retrieved Jan 26, 2020. 
  10. Spoonseeker, Author (Jul 3, 2017). "Spotlight on GETSET Julie". spoonseekerdotcom. Retrieved Jan 26, 2020. 
  11. "Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet". Phoenix Rising ME / CFS Forums. Retrieved Jan 26, 2020. 
  12. Corsius, Lou (Jun 23, 2017). "Yet another publication with misleading conclusions from PACE-land". it's about ME (in Nederlands). Retrieved Jan 26, 2020. 
  13. Johnson, Cort (Jun 26, 2017). "On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again)". Health Rising. Retrieved Jan 26, 2020. 

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.