File:Fibromyalgia-brain.jpg

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Brain abnormalities in fibromyalgia.
[11C]PBR28 VT was elevated in several brain regions compared to healthy control subjects (Fig. 1), including dorsolateral prefrontal cortex (dlPFC), dorsomedial PFC (dmPFC), primary somatosensory and motor cortices (S1/M1), precuneus, posterior cingulate cortex (PCC), supplementary motor area (SMA), supramarginal gyrus (SMG), and superior parietal lobule (SPL). Additionally, an ROI analysis of the aMCC revealed elevated VT in the FM patients that approached statistical significance (p = 0.071). There were no regions where control VT was significantly higher than FM VT.

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Albrecht, Daniel S.; Forsberg, Anton; Sandström, Angelica; Bergan, Courtney; Kadetoff, Diana; Protsenko, Ekaterina; Lampa, Jon; Lee, Yvonne C.; Höglund, Caroline Olgart (January 1, 2019). "Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation". Brain, Behavior, and Immunity. 75: 72–83. doi:10.1016/j.bbi.2018.09.018. ISSN 0889-1591. Albrecht, Daniel S., et al. "Brain glial activation in fibromyalgia–A multi-site positron emission tomography investigation." Brain, behavior, and immunity 75 (2019): 72-83.

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Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation^[1]

Fig. 1. Voxelwise group differences in [11C]PBR28 VT. A: Surface projection maps displaying areas with significantly elevated [11C]PBR28 VT in FM patients compared to controls (FM – n = 11; HC – n = 11) in voxelwise analyses (KI-only sample). B: average ± standard deviation VT extracted from several regions. The S1/M1, dLPFC and precuneus data were extracted from the clusters identified as statistically significant in the voxelwise VT analysis. For these regions, the plots are displayed for illustrative purposes only, and the level of statistical significance noted for each plot reflects that of the voxelwise analyses. For the aMCC, the data was extracted from a region independently identified based on the results of the SUVR voxelwise analysis (see Fig. 2).

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