File:Genetics ME-CFS-Perez-Klimas-2019.jpg

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Title: (or description)[edit | edit source]

Functional analysis of SNPs identified three main clusters of pathways as sharing at least 30% SNP related genes.

  • Immune-related SNPs: Cytokine Signaling in Immune System pathway; includes other immune-related pathways such as interferon signaling, autoimmune responses, and T-cell receptor signaling.
  • Hormone-related SNPs: Nuclear-Receptors Meta-Pathway and includes hormone related pathways such as steroid hormone, estrogen, and androgen biosynthesis, glucuronidation, and the pregnane x receptor pathway.
  • Metabolism-related SNPs: Pathways in Cancer, however, closer inspection shows many metabolic processes such as enzyme reactions (protein kinase A, calcium and calmodulin signaling), and G proteins signaling which regulate metabolic enzymes, which are all involved in the regulation of glycogen, sugar and lipid metabolism.

Author: (or citation)[edit | edit source]

Perez M, Juandoo R, Hilton K, Del Alamo A, Gemayel K, Klimas NG, Craddock TJA, Nathanson L (2019). Front. Pediatr. 7(206). doi: 10.3389/fped.2019.00206

Source: (e.g. internet address)[edit | edit source]

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study Figure 1.

Other information:[edit | edit source]

Pathway overlap networks in ME/CFS.
Pathways identified via over-representation analysis (nodes) connected by shared genes with SNPs (edges). Upper panel gives total number of SNPs per pathway and likelihood of annotation (p-value). Lower panel shows pathways most affected by deleterious SNPs.

See also[edit | edit source]

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single nucleotide polymorphism (SNP) - A single nucleotide polymorphism (SNP, pronounced "snip") is a potential genetic mutation that occurs in a single spot in the human genome; a difference in a single DNA building block. SNPs are often represented by an "rs" number, such as "rs53576".

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

T cell A type of white blood cell which is mostly produced or matured in the thymus gland (hence T-cell) and is involved in the adaptive immune response on a cellular level. Also known as a T lymphocyte. (Learn more: www.youtube.com)

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

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current20:50, September 29, 2020Thumbnail for version as of 20:50, September 29, 20201,036 × 1,339 (833 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== '''Functional analysis of SNPs identified three main clusters of pathways as sharing at least 30% SNP related genes.''' * '''Immune-related SNPs''': Cytokine Signaling in Immune System pathway; includes other immune-re...

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