Genetics of chronic fatigue syndrome
The genetics of chronic fatigue syndrome is an area of research as ME/CFS has been observed in families. It is unknown if there is a genetic link or common environmental exposure (infectious or toxic). Studies of twins show higher rates of ME/CFS in identical than fraternal twins. The Centers for Disease Control and Prevention (CDC) notes that specific genetic associations have not been established.
ME/CFS Gene Study[edit | edit source]
The ME/CFS Gene Study is still collecting data, but the initial pilot study by Perez et al. (2019) found 10 relatively common genes or gene variants were significantly more common in people with ME/CFS. These were CYP2D6, PRRT4, PRSS56, C14orf37, ANKDD1B, GPBAR1, LHB, ADAMTS19, VARS2, and CPLX2.
Utah Population Database study[edit | edit source]
A 2011 study by Albright et al showed evidence of a heritable contribution to chronic fatigue syndrome (CFS). Using the extensive records of the Utah Population Database (UPDB), the study "shows clear evidence of significant excess familial clustering and significantly elevated risks for CFS among first, second, and third degree relatives of CFS cases. The results strongly support a genetic contribution to predisposition to CFS as it is currently defined and diagnosed by clinicians in Utah." Increased outbreak rates in first degree relatives are not automatically assumed to be genetic because the first degree relatives often share the same lifestyle and environment. However, a significantly increased incidence (95% confidence interval) in second and third degree relatives strongly indicated a genetic contribution to CFS, given the much lower likelihood of these relatives sharing common risks and environments.
Family history and twin studies[edit | edit source]
A 2001 study in the UK showed "there were significantly higher rates of CFS in the relatives of CFS cases compared with the relatives of control subjects." Three twin studies (one in Australia, one in Washington, US, both in 2001, and one in the UK in 2007) showed that the correlations for prolonged and chronic fatigue were significantly higher in monozygotic than dizygotic twins for each definition of chronic fatigue syndrome.
Haplogroups[edit | edit source]
HLA alleles[edit | edit source]
Human leukocyte antigen genes associations were investigated by Lande et al. (2020) because these gene variants are considered hallmarks for autoimmune disease; two HLA associations were found to be more common in ME/CFS patients, but the majority of ME/CFS patients did not have these.
Notable studies[edit | edit source]
- 2001, A twin study of chronic fatigue(Abstract)
- 2006, Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes
Three genes were found to be common in a group of people with Chronic Fatigue Syndrome compared to the general population; TPH2 - neuronal tryptophan hydroxylase, COMT - catechol-O-methyltransferase, and NR3C1 - nuclear receptor subfamily 3, group C, member 1 glucocorticoid receptor, together these three have an accuracy of 76%.
- 2011, Evidence for a heritable predisposition to Chronic Fatigue Syndrome(Abstract)
- 2011, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome
- 2016, Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome(Full Text)
- 2016, Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (Abstract)
- 2018, Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns(Abstract)
- 2018, Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.(Abstract)
- 2019, Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome.(Abstract)
- 2019 - Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study(Full text)
- 2020, Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - (Full text)
- 2020, Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender‐specific changes in the microRNA expression profiling in ME/CFS - (Full text)
Media Coverage[edit | edit source]
- 2016, Genome-wide associations
- 2016, New study found SNPs for some symptoms (CFS Remission, January 23)
See also[edit | edit source]
Learn more[edit | edit source]
- Mitochondrial DNA and ME/CFS - A Guide to the Hanson Lab's - 2016 JTM Publication
References[edit | edit source]
- "Etiology and Pathophysiology | Presentation and Clinical Course | Healthcare Providers | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | CDC". www.cdc.gov. Nov 8, 2018. Retrieved Feb 8, 2019.
- Nathanson, Lubov; Craddock, Travis J. A.; Klimas, Nancy G.; Gemayel, Kristina; Del Alamo, Ana; Hilton, Kelly; Jaundoo, Rajeev; Perez, Melanie (2019). "Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00206. ISSN 2296-2360.
- Albright, Frederick; Light, Kathleen; Light, Alan; Bateman, Lucinda; Cannon-Albright, Lisa A (2011), "Evidence for a heritable predisposition to Chronic Fatigue Syndrome", BMC Neurology, 11 (62), doi:10.1186/1471-2377-11-62
- Walsh, C. M.; Zainal, N. Z.; Middleton, S. J.; Paykel, E. S. (Sep 2001). "A family history study of chronic fatigue syndrome". Psychiatric Genetics. 11 (3): 123–128. doi:10.1097/00041444-200109000-00003. ISSN 0955-8829.
- Buchwald, D.; Herrell, R.; Ashton, S.; Belcourt, M.; Schmaling, K.; Sullivan, P.; Neale, M.; Goldberg, J. (2001), "A twin study of chronic fatigue.", Psychosomatic Medicine, 63 (6): 936-943, PMID 11719632
- Hickie, IB; Bansal, AS; Kirk, KM; Lloyd, AR; Martin, NG (2001), "A twin study of the etiology of prolonged fatigue and immune activation", Twin Research, 4 (2): 94-102, doi:10.1375/1369052012209
- Schur, Ellen; Afari, Niloofar; Goldberg, Jack; Buchwald, Dedra; Sullivan, Patrick F. (2007), "Twin analyses of fatigue", Twin Research and Human Genetics, 10 (5): 729-733, doi:10.1375/twin.10.5.729
- Billing-Ross, Paul; Germain, Arnaud; Ye, Kaixiong; Keinan, Alon; Gu, Zhenglong; Hanson, Maureen R. (Jan 20, 2016). "Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome". Journal of Translational Medicine. 14 (1): 19. doi:10.1186/s12967-016-0771-6. ISSN 1479-5876.
- Lande, Asgeir; Fluge, Øystein; Strand, Elin B.; Flåm, Siri T.; Sosa, Daysi D.; Mella, Olav; Egeland, Torstein; Saugstad, Ola D.; Lie, Benedicte A. (Mar 24, 2020). "Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Scientific Reports. 10 (1): 1–8. doi:10.1038/s41598-020-62157-x. ISSN 2045-2322.
- Goertzel, Benjamin N.; Pennachin, Cassio; de Souza Coelho, Lucio; Gurbaxani, Brian; Maloney, Elizabeth M.; Jones, James F. (April 2006). "Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome". Pharmacogenomics. 7 (3): 475–483. doi:10.2217/146224188.8.131.525. ISSN 1462-2416. PMID 16610957.
- Light, A. R.; Bateman, L.; Jo, D.; Hughen, R. W.; VanHaitsma, T. A.; White, A. T.; Light, K. C. (Jul 13, 2011). "Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome". Journal of Internal Medicine. 271 (1): 64–81. doi:10.1111/j.1365-2796.2011.02405.x. ISSN 0954-6820. PMC . PMID 21615807.
- Schlauch, Karen A.; Khaiboullina, Svetlana F.; De Meirleir, Kenny L.; Rawat, Shanti; Petereit, J; Rizvanov, Albert A; Blatt, Nataliya; Mijatovic, Tatjana; Kulick, D; Palotás, András; Lombardi, Vincent C. (2016), "Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome", Translational Psychiatry, 6 (2): e730, doi:10.1038/tp.2015.208
- Trivedi, Malav S.; Oltra, Elisa; Sarria, Leonor; Rose, Natasha; Beljanski, Vladimir; Fletcher, Mary Ann; Klimas, Nancy G.; Nathanson, Lubov (2018). "Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns". PloS One. 13 (7): e0201066. doi:10.1371/journal.pone.0201066. ISSN 1932-6203. PMID 30036399.
- Herrera, Santiago; de Vega, Wilfred C.; Ashbrook, David; Vernon, Suzanne D.; McGowan, Patrick O. (Dec 5, 2018). "Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Epigenetics: 1–17. doi:10.1080/15592294.2018.1549769. ISSN 1559-2308. PMID 30516085.
- Nguyen, Chinh Bkrong; Kumar, Surendra; Zucknick, Manuela; Kristensen, Vessela N.; Gjerstad, Johannes; Nilsen, Hilde; Wyller, Vegard Bruun (Feb 2019). "Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome". Brain, Behavior, and Immunity. 76: 82–96. doi:10.1016/j.bbi.2018.11.008. ISSN 1090-2139. PMID 30419269.
- Cheema, Amanpreet K.; Sarria, Leonor; Bekheit, Mina; Collado, Fanny; Almenar‐Pérez, Eloy; Martín‐Martínez, Eva; Alegre, Jose; Castro‐Marrero, Jesus; Fletcher, Mary A.; Klimas, Nancy; Oltra, Elisa; Nathanson, Lubov (Apr 14, 2020). "Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS". Journal of Cellular and Molecular Medicine. 00: 1–13. doi:10.1111/jcmm.15260. ISSN 1582-4934. PMID 32291908.