File:ME-CFS-biological differences.png

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Differences in mitochondrion proteins between ME/CFS patients and healthy controls - increased proteins in ME/CFS (left) and decreased proteins (right).

Author: (or citation)[edit | edit source]

Sweetman, Kleffmann, Edgar, de Lange, Vallings and Tate (2020). A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction - (Full text)

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Journal of Translational Medicine 18(1):365 Sweetman et al. 2020.
doi: 10.1186/s12967-020-02533-3. PMC7512220

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myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

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Date/TimeThumbnailDimensionsUserComment
current15:32, September 26, 2020Thumbnail for version as of 15:32, September 26, 20201,960 × 882 (1.04 MB)Notjusttired (talk | contribs)==== Title: (or description) ==== Differences in mitochondrion proteins between ME/CFS patients and healthy controls - increased proteins in ME/CFS (left) and decreased proteins (right). ==== Author: (or citation) ==== Sweetman, Kleffm...

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