Idiopathic chronic fatigue

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Source: Chronic fatigue syndrome: A review (Balachander et al.) 2014.[1]

Idopathic chronic fatigue or ICF is long lasting chronic fatigue that is not caused by an underlying medical condition or psychiatric illness.[2] Patients with idopathic chronic fatigue do not fulfill the criteria for chronic fatigue syndrome (CFS).[3] The word idiopathic reflects an unknown underlying cause, meaning that the chronic fatigue is a medically unexplained symptom.[2][4]

Differences from chronic fatigue syndrome[edit | edit source]

Chronic Fatigue Syndrome (CFS) is a distinct neurological disease, and is not the same as chronic fatigue, or long-term fatigue with no known cause (ICF).[3]Source: Son, C-G (2019). Differential diagnosis between “chronic fatigue” and “chronic fatigue syndrome”. Integrative Medicine Research, 8(2), 89-91. Suggested algorithm for chronic fatigue, ICF and CFS. License: CC-BY-ND-NC.
  • Idiopathic chronic fatigue is not a distinct illness or disease
  • Idiopathic chronic fatigue only requires the symptom of chronic fatigue[3]
  • Idiopathic chronic fatigue is more common in the elderly and becomes more common with ageing[2]
  • Chronic fatigue syndrome is a neurological disease
  • Chronic fatigue syndrome has a multi-systemic illness with a wide variety of symptoms, which may include immune symptoms, cardiovascular symptoms, post-exertional malaise, headaches or migraines, and chronic pain.[3][5]
  • Chronic fatigue syndrome is most common in teenagers and working age adults
  • Idiopathic chronic fatigue is generally considered less disabling[2]

Notable studies[edit | edit source]

  • 1992, Chronic tiredness and idiopathic chronic fatigue--a connection?[6] - (Abstract)
  • 1999, Idiopathic chronic fatigue and chronic fatigue syndrome: a comparison of two case-definitions[7] - (Abstract)
  • 2004, Disability in chronic fatigue syndrome and idiopathic chronic fatigue[8] - (Full text)
  • 2007/updated 2009, Traditional Chinese medicinal herbs for idiopathic chronic fatigue and chronic fatigue syndrome[9] - (Full text)
  • 2012, Fatigue severity of patients with idiopathic chronic fatigue compared to healthy subjects[10] - (Full text)
  • 2013, Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle[11] - (Full text)
  • 2013, Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course[12] - (Full text)
  • 2013, An open-label study of effects of acupuncture on chronic fatigue syndrome and idiopathic chronic fatigue: study protocol for a randomized controlled trial[13] - (Full text)
  • 2014, Chronic fatigue syndrome: A review[1] (Full Text)
  • 2016, Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue[2](Full text)
  • 2019, Differential diagnosis between “chronic fatigue” and “chronic fatigue syndrome”[3] - (Full source)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.1 Singh, Shubh Mohan; Sarkar, Siddharth; Rao, Pradyumna; Balachander, Srinivas (Jul 1, 2014). "Chronic fatigue syndrome: A review". Medical Journal of Dr. D.Y. Patil University. 7 (4): 415. doi:10.4103/0975-2870.135252. ISSN 0975-2870. 
  2. 2.02.12.22.32.4 Manini, Todd M.; Knaggs, Jeffrey D.; Corbett, Duane B.; Valiani, Vincenzo (Nov 1, 2016). "Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue". The Journals of Gerontology: Series A. 71 (11): 1444–1450. doi:10.1093/gerona/glw108. ISSN 1079-5006. 
  3. 3.03.13.23.33.4 Son, Chang-Gue (Jun 2019). "Differential diagnosis between "chronic fatigue" and "chronic fatigue syndrome"". Integrative medicine research. 8 (2): 89–91. doi:10.1016/j.imr.2019.04.005. ISSN 2213-4220. PMID 31193269. 
  4. 4.04.1 Sigurdsson MD, Alex F. (Nov 8, 2017). "19 Important Causes of Fatigue - Tiredness and Chronic Fatigue Explained". www.docsopinion.com. Retrieved Jan 30, 2019. 
  5. Fukuda, K.; Straus, S. E.; Hickie, I.; Sharpe, M. C.; Dobbins, J. G.; Komaroff, A. (Dec 15, 1994). "The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group" (PDF). Annals of Internal Medicine. American College of Physicians. 121 (12): 953–959. ISSN 0003-4819. PMID 7978722. 
  6. Simpson, LO (Mar 1992). "Chronic Tiredness and Idiopathic Chronic Fatigue--A Connection?". New Jersey medicine. 89 (3): 211‐216. PMID 1574202. Retrieved May 22, 2020. 
  7. C, Arpino; Mp, Carrieri; G, Valesini; E, Pizzigallo; P, Rovere; U, Tirelli; F, Conti; P, Dialmi; A, Barberio (1999). "Idiopathic Chronic Fatigue and Chronic Fatigue Syndrome: A Comparison of Two Case-Definitions". Annali dell'Istituto superiore di sanita. PMID 10721210. Retrieved May 22, 2020. 
  8. Carrico, Adam W.; Jason, Leonard A.; Witter, Elizabeth; Torres-Harding, Susan (2004). "Disability in Chronic Fatigue Syndrome and Idiopathic Chronic Fatigue". Review of Disability Studies: An International Journal. 1 (1). ISSN 1552-9215. 
  9. Adams, Denise; Wu, Taixiang; Tai, Shusheng; Wiebe, Natasha; Vohra, Sunita (2007). "Traditional Chinese medicinal herbs for idiopathic chronic fatigue and chronic fatigue syndrome". Cochrane Database of Systematic Reviews (1). doi:10.1002/14651858.CD006348. ISSN 1465-1858. 
  10. Lee, Nam Hun; Son, Chang Gue (Sep 1, 2012). "Fatigue severity of patients with idiopathic chronic fatigue compared to healthy subjects". Journal of Traditional Chinese Medicine. 32 (3): 355–357. doi:10.1016/S0254-6272(13)60037-0. ISSN 0254-6272. 
  11. Wawrzyniak, Nicholas R.; Joseph, Anna-Maria; Levin, David G.; Gundermann, David M.; Leeuwenburgh, Christiaan; Sandesara, Bhanuprasad; Manini, Todd M.; Adhihetty, Peter J. (Jul 18, 2016). "Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle". Oncotarget. 7 (33): 52695–52709. doi:10.18632/oncotarget.10685. ISSN 1949-2553. PMC 5288142Freely accessible. PMID 27447862. 
  12. Mørch, Kristine; Hanevik, Kurt; Rivenes, Ann C.; Bødtker, Jørn E.; Næss, Halvor; Stubhaug, Bjarte; Wensaas, Knut-Arne; Rortveit, Guri; Eide, Geir E. (Feb 12, 2013). "Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course". BMC Gastroenterology. 13 (1): 28. doi:10.1186/1471-230X-13-28. ISSN 1471-230X. PMC 3598369Freely accessible. PMID 23399438. 
  13. Kim, Jung-Eun; Hong, Kwon-Eui; Kim, Hyeong-Jun; Choi, Jin-Bong; Baek, Yong-Hyeon; Seo, Byung-Kwan; Lee, Sanghun; Kang, Kyung-Won; Lee, Min-Hee (May 21, 2013). "An open-label study of effects of acupuncture on chronic fatigue syndrome and idiopathic chronic fatigue: study protocol for a randomized controlled trial". Trials. 14 (1): 147. doi:10.1186/1745-6215-14-147. ISSN 1745-6215. PMC 3663812Freely accessible. PMID 23693129. 

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