Lactic acidosis occurs when too much lactic acid builds up in the bloodstream. Lactic acidosis can be caused by excessive l-lactate (l-lactic acid) or excessive d-lactate (d-lactic acid). While D-lactic acidosis is less common, increased levels of d-lactic acid and ensuing d-lactic acidosis have been linked to ME/CFS on numerous occasions.
There is also a significant correlation between cognitive dysfunction and neurological impairment symptoms in ME/CFS and those found in patients with d-lactic acidosis.
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- Sheedy, John R.; Wettenhall, Richard E. H.; Scanlon, Denis; Gooley, Paul R.; Lewis, Donald P.; McGregor, Neil; Stapleton, David I.; Butt, Henry L.; De Meirleir, Kenny L. (July 2009). "Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome". In Vivo (Athens, Greece). 23 (4): 621–628. ISSN 0258-851X. PMID 19567398.