Neuroimmune model

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

The neuroimmune model or neuro immune hypothesis of ME/CFS proposes that an initial infection and immune activation, which can be caused by a number of different pathogens results in "a state of chronic peripheral immune activation driven by activated O&NS pathways that lead to progressive damage of self epitopes even when the initial infection has been cleared".[1]

The ATP deficiency, inflammation and oxidative and nitrosative stress are proposed to result from this, and to be the cause of the symptoms characteristic of ME/CFS.[1]

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