CureME

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CureME is a British research group at the London School of Hygiene and Tropical Medicine (LSHTM), undertaking clinical and biomedical research into ME/CFS. The team is led by Luis Nacul.[1]

Overview[edit | edit source]

The group conducts clinical, epidemiological and laboratory research into ME/CFS, and is comprised of a clinical team led by Luis Nacul and Eliana Lacerda and a laboratory team led by Hazel Dockrell and Jacqueline Cliff.[2]

The group is midway through an eight-year major study into ME/CFS funded by the National Institutes of Health, which is seeking to create results through integrated desk and laboratory research, over an extended timespan and using a large number of participants.[3]

The team is overseen by a Steering Committee that includes researchers, partner charities and patient/carer representatives.

The UK ME/CFS Biobank[edit | edit source]

In August 2011, the team founded a biobank for Myalgic Encephalomyelitis, hosted by the University College London Biobank at the Royal Free Hospital.[4][5] The UK ME/CFS Biobank (UKMEB) was initially funded with support from ME Research UK, the ME Association and Action for ME as well as private donors.[4] Ongoing funding has been provided by the ME Association and the US National Institutes of Health.[6][7]

The Biobank holds over 30,000 aliquots of blood from people with ME, MS and healthy controls, with accompanying clinical data.[8] In 2016 the Biobank's samples were made available to researchers around the world, and any researcher can apply to use samples and/or clinical data, subject to application approval and ethical clearance.[9]

Notable people[edit | edit source]

As of January 2019, the members of the group include:[10]

Notable studies[edit | edit source]

  • 2011, Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care[11]
  • 2011, Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis[12]
  • 2014, Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol[13]
  • 2017, How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?[14]
  • 2017, Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome[15]
  • 2017, Prevalence of and risk factors for severe cognitive and sleep symptoms in ME/CFS and MS[16]
  • 2017, The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis[17]
  • 2017, The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE[18]
  • 2017, Using a participatory approach to develop and implement the UK ME/CFS Biobank[19]
  • 2018, Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls[20]
  • 2018, Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe-the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review[21]
  • 2018, The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[22](Full text)
  • 2019, Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study.[23]
  • 2019, Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[24] - (Full text)

Talks and interviews[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "CureMe – Driving research into ME/CFS". Retrieved Jun 3, 2020. 
  2. "People – CureMe". Retrieved Jun 3, 2020. 
  3. "Research – CureMe". Retrieved Jun 3, 2020. 
  4. 4.04.1 "History of CureME". CureMe. Retrieved Jan 18, 2019. 
  5. Action for M.E. AGM 2013 part three
  6. UK ME/CFS Biobank project awarded £1 million grant
  7. Current Research 2015
  8. "Samples & Data". CureMe. Retrieved Jan 18, 2019. 
  9. "Accessing the Biobank – CureMe". Retrieved Jun 3, 2020. 
  10. "People". CureMe. Retrieved Jan 18, 2019. 
  11. Nacul, Luis C.; Lacerda, Eliana M.; Pheby, Derek; Campion, Peter; Molokhia, Mariam; Fayyaz, Shagufta; Leite, Jose CDC; Poland, Fiona; Howe, Amanda (Jul 28, 2011). "Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care". BMC Medicine. 9 (1): 91. doi:10.1186/1741-7015-9-91. ISSN 1741-7015. PMC 3170215Freely accessible. PMID 21794183. 
  12. de Carvalho Leite, Jose C.; de L Drachler, Maria; Killett, Anne; Kale, Swati; Nacul, Luis; McArthur, Maggie; Hong, Chia Swee; O'Driscoll, Lucy; Pheby, Derek (Nov 2, 2011). "Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis". International Journal for Equity in Health. 10 (1): 46. doi:10.1186/1475-9276-10-46. ISSN 1475-9276. PMC 3229491Freely accessible. PMID 22044797. 
  13. Nacul, Luis; O’Donovan, Dominic G.; Lacerda, Eliana M.; Gveric, Djordje; Goldring, Kirstin; Hall, Alison; Bowman, Erinna; Pheby, Derek (Jun 18, 2014). "Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol". BMC Research Notes. 7 (1): 370. doi:10.1186/1756-0500-7-370. ISSN 1756-0500. PMC 4076507Freely accessible. PMID 24938650. 
  14. Nacul, Luis; Lacerda, Eliana M.; Kingdon, Caroline C.; Curran, Hayley; Bowman, Erinna W. (Mar 1, 2017). "How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?". Journal of Health Psychology: 1359105317695803. doi:10.1177/1359105317695803. ISSN 1461-7277. PMC 5581258Freely accessible. PMID 28810428. 
  15. Nacul, Luis; Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Lacerda, Eliana M. (2017). "Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 5 (1): 1–4. doi:10.1080/21641846.2017.1273863. ISSN 2164-1846. PMC 5730342Freely accessible. PMID 29250461. 
  16. Jain, Vageesh; Arunkumar, Amit; Kingdon, Caroline; Lacerda, Eliana; Nacul, Luis (Jun 20, 2017). "Prevalence of and risk factors for severe cognitive and sleep symptoms in ME/CFS and MS". BMC Neurology. 17 (1): 117. doi:10.1186/s12883-017-0896-0. ISSN 1471-2377. PMC 5477754Freely accessible. PMID 28633629. 
  17. Nacul, Luis; Curran, Hayley; Riley, Eleanor; Dockrell, Hazel; Clark, Taane; Lee, Ji-Sook; King, Elizabeth; Kingdon, Caroline; Cliff, Jacqueline (Feb 20, 2017). "The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis". Open Journal of Bioresources. 4 (1): 4. doi:10.5334/ojb.28. ISSN 2056-5542. PMC 5482226Freely accessible. PMID 28649428. 
  18. Scheibenbogen, Carmen; Freitag, Helma; Blanco, Julià; Capelli, Enrica; Lacerda, Eliana; Authier, Jerome; Meeus, Mira; Castro Marrero, Jesus; Nora-Krukle, Zaiga (Jul 26, 2017). "The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE". Journal of Translational Medicine. 15 (1): 162. doi:10.1186/s12967-017-1263-z. ISSN 1479-5876. PMC 5530475Freely accessible. PMID 28747192. 
  19. Lacerda, Eliana M.; Kingdon, Caroline C.; Bowman, Erinna W.; Nacul, Luis (2018). "Using a participatory approach to develop and implement the UK ME/CFS Biobank". Fatigue: Biomedicine, Health & Behavior. 6 (1): 1–4. doi:10.1080/21641846.2018.1396021. ISSN 2164-1846. PMID 29938127. 
  20. Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Nacul, Luis; Lacerda, Eliana M. (Dec 1, 2018). "Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls". PharmacoEconomics - Open. 2 (4): 381–392. doi:10.1007/s41669-018-0071-6. ISSN 2509-4254. PMID 29536371. 
  21. Murovska, Modra; Lacerda, Eliana; Sekulic, Slobodan; Capelli, Enrica; Lorusso, Lorenzo; Shikova, Evelina; Scheibenbogen, Carmen; Alegre, Jose; Pheby, Derek (Sep 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183. 
  22. Lacerda, Eliana; Mudie, Kathleen; Butterworth, Jack D.; Kingdon, Caroline C.; O'Boyle, Shennae; Nacul, Luis (Dec 4, 2018). "The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.01026. ISSN 1664-2295. PMID 30564186. 
  23. Lacerda, Eliana M.; McDermott, Clare; Kingdon, Caroline C.; Butterworth, Jack; Cliff, Jacqueline M.; Nacul, Luis (Jan 10, 2019). "Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study". Health Expectations: An International Journal of Public Participation in Health Care and Health Policy. doi:10.1111/hex.12857. ISSN 1369-7625. PMID 30632248. 
  24. Cliff, Jacqueline M.; King, Elizabeth C.; Lee, Ji-Sook; Sepúlveda, Nuno; Wolf, Asia-Sophia; Kingdon, Caroline; Bowman, Erinna; Dockrell, Hazel M.; Nacul, Luis; Lacerda, Eliana; Riley, Eleanor (Apr 16, 2019). "Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.00796. ISSN 1664-3224. 

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.