Luis Nacul

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Dr Luis Carlos Nacul is a Clinical Associate Professor and researcher at the London School of Hygiene and Tropical Medicine in London, United Kingdom. He leads the CureME team and the UK ME/CFS biobank. He serves as a Member Substitute for EUROMENE, an international not-for-profit organization for ME/CFS research.

He is a doctor and general practitioner, with training across medicine, epidemiology and public health.[1] In 2018, Dr Nacul was appointed to the review committee for the NICE guidelines for ME/CFS used by the British NHS.[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Dr Nacul serves on the Fatigue Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control & Prevention.[3]

Notable studies and writings related to ME/CFS[edit | edit source]


Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. London School of Hygiene and Tropical Medicine. "Luis Nacul". 
  2. NICE (Oct 28, 2018). "Committee member list | NICE CG53 CFS/ME guidance update". nice.org.uk. Retrieved Oct 20, 2018. 
  3. "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019. 
  4. Osoba, Tolu; Pheby, Derek; Gray, Selena; Nacul, Luis (2007), "The Development of an Epidemiological Definition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 14 (4): 61-84, doi:10.3109/10573320802092112 
  5. Nacul, L. C.; Lacerda, E. M.; Pheby, D.; Campion, P.; Molokhia, M.; Fayyaz, S.; Leite, JCDC; Poland, F; Howe, A; Drachler, Maria (2011). "Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care". BMC Medicine. 9 (91). doi:10.1186/1741-7015-9-91. PMC 3170215Freely accessible. 
  6. de Carvalho Leite, JC; de L Drachler, M; Killett, A; Kale, S; Nacul, L; McArthur, M; Hong, CS; O'Driscoll, L; Pheby, D; Campion, P; Lacerda, E; Poland, F (2011), "Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis", International Journal for Equity in Health, 2 (10): 46, doi:10.1186/1475-9276-10-46, PMC 3229491Freely accessible 
  7. Nacul, Luis C; Lacerda, Eliana M; Campion, Peter; Pheby, Derek; Drachler, Maria de L; Leite, José C; Poland, Fiona; Howe, Amanda; Fayyaz, Shagufta (May 27, 2011). "The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers". BMC Public Health. 11 (1). doi:10.1186/1471-2458-11-402. ISSN 1471-2458. PMC 3123211Freely accessible. PMID 21619607. 
  8. Nacul, Luis; O’Donovan, Dominic G; Lacerda, Eliana M; Gveric, Djordje; Goldring, Kirstin; Hall, Alison; Bowman, Erinna; Pheby, Derek (2014). "Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol". BMC Research Notes. 7 (1): 370. doi:10.1186/1756-0500-7-370. ISSN 1756-0500. PMC 4076507Freely accessible. PMID 24938650. 
  9. Nacul, Luis; Lacerda, Eliana M; Kingdon, Caroline C; Curran, Hayley; Bowman, Erinna W (Mar 1, 2017). "How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?". Journal of Health Psychology: 1359105317695803. doi:10.1177/1359105317695803. ISSN 1359-1053. PMC 5581258Freely accessible. PMID 28810428. 
  10. Cella, David; Dimmock, Mary; Friedberg, Fred; Lin, Jin-Mann Sally; Nacul, Luis; Saligan, Leorey (Dec 2017), NINDS/CDC Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials (PDF) 
  11. Lacerda, Eliana M.; Kingdon, Caroline C.; Bowman, Erinna W.; Nacul, Luis (2017). "Using a participatory approach to develop and implement the UK ME/CFS Biobank". Fatigue: Biomedicine, Health & Behavior. doi:10.1080/21641846.2018.1396021. 
  12. Nacul, Luis; Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Lacerda, Eliana M. (2017). "Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 5 (1): 1–4. doi:10.1080/21641846.2017.1273863. ISSN 2164-1846. PMC 5730342Freely accessible. PMID 29250461. 
  13. Lacerda, Eliana M; Bowman, Erinna W; Cliff, Jacqueline M; Kingdon, Caroline C; King, Elizabeth C; Lee, Ji-Sook; Clark, Taane G; Dockrell, Hazel M; Riley, Eleanor M; Curran, Hayley; Nacul, Luis (Feb 20, 2017). "The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis". Open Journal of Bioresources. 4. doi:10.5334/ojb.28. ISSN 2056-5542. PMC 5482226Freely accessible. PMID 28649428. 
  14. Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Nacul, Luis; Lacerda, Eliana M. (Mar 13, 2018). "Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls". PharmacoEconomics - Open. doi:10.1007/s41669-018-0071-6. ISSN 2509-4262. 
  15. Estévez-López, Fernando; Castro-Marrero, Jesus; Wang, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Nacul, Luis; Sepúlveda, Nuno; Strand, Elin B.; Pheby, Derek; Alegre, José; Scheibenbogen, Carmen; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Lacerda, Eliana; Murovska, Modra (Sep 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183. 
  16. Nacul, Luis Carlos; Mudie, Kathleen; Kingdon, Caroline; Clark, Taane G.; Lacerda, Eliana Mattos (2018). "Hand grip strength as a clinical biomarker for ME/CFS and disease severity". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.00992. ISSN 1664-2295. 
  17. Lacerda, Eliana; Mudie, Kathleen; Butterworth, Jack D.; Kingdon, Caroline C.; O'Boyle, Shennae; Nacul, Luis (Dec 4, 2018). "The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.01026. ISSN 1664-2295. PMID 30564186. 
  18. Lacerda, Eliana M.; McDermott, Clare; Kingdon, Caroline C.; Butterworth, Jack; Cliff, Jacqueline M.; Nacul, Luis (Jan 10, 2019). "Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study". Health Expectations. 0 (0). doi:10.1111/hex.12857. ISSN 1369-7625. PMID 30632248. 
  19. Nacul, Luis; de Barros, Barbara; Kingdon, Caroline C.; Cliff, Jacqueline M.; Clark, Taane G.; Mudie, Kathleen; Dockrell, Hazel M.; Lacerda, Eliana M. (Apr 10, 2019). "Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study". Diagnostics. 9 (2): 41. doi:10.3390/diagnostics9020041. ISSN 2075-4418. 
  20. Cliff, Jacqueline M.; King, Elizabeth C.; Lee, Ji-Sook; Sepúlveda, Nuno; Wolf, Asia-Sophia; Kingdon, Caroline; Bowman, Erinna; Dockrell, Hazel M.; Nacul, Luis; Lacerda, Eliana; Riley, Eleanor (Apr 16, 2019). "Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.00796. ISSN 1664-3224. 
  21. Rodrigues, Lucas S; Nali, Luiz H da Silva; Leal, Cibele O D; Sabino, Ester C; Lacerda, Eliana M; Kingdon, Caroline C; Nacul, Luis; Romano, Camila M (Jul 5, 2019). "HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome". bioRxiv. doi:10.1101/693465. 
  22. Sepúlveda, Nuno; Carneiro, Jorge; Eliana M. Lacerda, Eliana M.; Nacul, Luis C. (Oct 2019). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a hyper-regulated immune system driven by an interplay between regulatory T cells and chronic human herpesvirus infections". Frontiers in Immunology. doi:10.3389/fimmu.2019.02684. 
  23. Lacerda, Eliana M.; Geraghty, Keith; Kingdon, Caroline C.; Palla, Luigi; Nacul, Luis (Dec 2019). "A logistic regression analysis of risk factors in ME/CFS pathogenesis". BMC Neurology. 19 (1): 275. doi:10.1186/s12883-019-1468-2. ISSN 1471-2377. 
  24. Friedberg, Fred; Sunnquist, Madison; Nacul, Luis (Mar 1, 2020). "Rethinking the Standard of Care for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of General Internal Medicine. 35 (3): 906–909. doi:10.1007/s11606-019-05375-y. ISSN 1525-1497. PMC 7080939Freely accessible. PMID 31637650. 
  25. Nacul, Luis; O'Boyle, Shennae; Nacul, Flavio E.; Mudie, Kathleen; Kingdon, Caroline C.; Cliff, Jacqueline M.; Clark, Taane G.; Dockrell, Hazel M.; Lacerda, Eliana M. (Sep 17, 2019). "How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS". Preprints. doi:10.20944/preprints201909.0188.v1. 
  26. Estévez-López, Fernando; Mudie, Kathleen; Wang-Steverding, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Castro-Marrero, Jesús; Nacul, Luis; Alegre, Jose; Zalewski, Paweł; Słomko, Joanna; Bolle Strand, Elin; Pheby, Derek; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Scheibenbogen, Carmen; Sepúlveda, Nuno; Murovska, Modra; Lacerda, Eliana (May 2020). "Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology". Journal of Clinical Medicine. 9 (5): 1557. doi:10.3390/jcm9051557. 

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