The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

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The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, published as The Nightingale Research Foundation Review of The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, as a classic book about myalgic encephalomyelitis by Dr Byron Hyde and other international experts.

The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Editors Byron Hyde
Authors Jay Goldstein, Paul Levine
Country Canada, United States
Language English
Subject Medical reference, medical research
Genre Medical
Publisher Nightingale Research Foundation
Publication date
1992
Media type print & digital
Pages 724
ISBN 978-0969566205, 0-9695662-0-4
Website https://www.nightingale.ca/publications

The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is a large reference book edited by Byron Hyde, Jay Goldstein, and Paul Levine. The book contains the proceedings from the first international symposium for clinicians and researchers in ME/CFS, held in Cambridge, England in April 1990. The symposium was organized by Dr. Byron Hyde of the Nightingale Research Foundation and Dr. John Richardson of the Newcastle Research Group. One of the honorary chairpeople of the symposium, Dr. Melvin Ramsay, who was instrumental in encouraging the idea of the symposium, passed away a few weeks before the symposium was to be held. His prepared remarks were included in the book. From the forward to the book:

We have attempted to obtain material in every area of M.E./CFS knowledge, but we have not always been successful. Some information is under copyright and could not be released. Some promised material just never arrived. Scientific knowledge of M.E./CFS is growing so rapidly that we were not always able to keep up with all of the explosive changes in information. To compensate for some of the omissions, Nightingale staff have written review chapters only when an appropriate contributor was not available or the chapter was delayed. These review chapters represent Nightingale's opinions and are not necessarily those of the clinicians and researchers mentioned. Furthermore, in a few cases, we have requested and obtained permission from certain prestigious journals to reproduce works of historical significance. Due to the sheer length of some of the original manuscripts, it was necessary for us to reproduce some of the authors' work in abstract form.

A PDF of the book is freely available to download from the Nightingale Research Foundation website.[1]

Publisher's synopsis[edit | edit source]

(This synopsis was provided by the publisher for promotional purposes. For book reviews, please see Links section below.)

Eighty of the world's leading M.E./CFS authorities have contributed their knowledge to produce a 750-page encyclopedia on the disease process that may be one of the biggest single causes of chronic illness in the world today. Known in the United States as Chronic Fatigue Syndrome and in Great Britain both as Myalgic Encephalomyelitis and Post-Viral Fatigue Syndrome, M.E./CFS has provoked a chronic disabling illness in an estimated 1,000,000 persons in North America and Europe.

This book provides, in one superb 75-chapter source, an up-to-date, comprehensive account of current knowledge concerning the history, epidemiology, children with M.E., investigation, virology, immunology, muscle pathology, host response, food intolerance, brain mapping, neurophysiology, neuropsychology, psychiatry, sleep dysfunction, fibromyalgia syndrome, treatment and management.

This is an essential reference book for medical, government and public library reference rooms. This text is a unique vehicle for researchers, physicians and other health education and government officials, and is easily understandable by the general public interested in M.E./CFS.

Contents[edit | edit source]

  • i. Magnetic Resonance Imaging (MRI)
  • ii. Dedication: Dr. John Richardson
  • iv-viii. Brain Imaging Illustrations
  • ix. Foreword
  • x. Preface: Unravelling the Enigma
  • xiv. In Appreciation

Section 1: A Road Map to M.E. / CFS / PVFS / CFIDS[edit | edit source]

  • Chapter 1: The Disease of a Thousand Names
  • Chapter 2: The Definitions of M.E./CFS, A Review
  • Chapter 3: A Description of Patients, Borys Chabursky, Byron Hyde, M.D., Anil Jain, M.D.
  • Chapter 4: General Information, Post Infectious, Acute Onset M.E./CFS, Byron Hyde, M.D., Sheila Bastien, Ph.D, Anil Jain, M.D.
  • Chapter 5: Clinical Observations of CNS Dysfunction in Post-Infectious, Acute Onset M.E./CFS, Byron Hyde, M.D., Anil Jain, M.D.
  • Chapter 6: M.E./CFS: The Physical Signs of Disease, Byron Hyde, M.D., Anil Jain, M.D.

Section 2: Opening Remarks of the Honorary Chairmen[edit | edit source]

Section 3: Opening Remarks of some of the Chairmen[edit | edit source]

Chairman J.E. Banatvala, MA., M.D., MRCP, FRCPath: England
Chairman Alan Smith, M.D.: South Africa

Section 4: An Historical Review of M.E./CFS Like Disease[edit | edit source]

Section 5: The Twentieth Century History of M.E./CFS[edit | edit source]

Section 6: The Epidemiology and Methodology of M.E./CFS[edit | edit source]

Section 7: Children and Students with M.E./CFS[edit | edit source]

Section 8: General Review[edit | edit source]

Section 9: Evaluating the M.E./CFS Patient[edit | edit source]

Section 10: The Infectious Origins of M.E./CFS[edit | edit source]

Subsection A: The Enteroviral Theories[edit | edit source]

Subsection B: The Retroviral Theories[edit | edit source]

Section 11: The Skeletal Muscle As Target[edit | edit source]

Section 12: The Heart As Target[edit | edit source]

  • Chapter 42: Cardiac and Cardiovascular Aspects of M.E./CFS, A Review, Byron Hyde, M.D., Anil Jain, M.D.

Section 13: Neurology[edit | edit source]

  • Chapter 43: The Differential Diagnosis Between Multiple Sclerosis and Chronic Fatigue Postviral Syndrome, Charles M. Poser, M.D.
  • Chapter 44: Neurological Features of M.E., Russell J.M. Lane, M.D.
  • Chapter 45: CFS: Limbic Encephalopathy in a Dysfunctional Neuroimmune Network, Jay Goldstein, M.D.

Section 14: M.E./CFS and the Peripheral Nervous System[edit | edit source]

  • Chapter 46: An Historical Review of the Electromyographic Features of Post-Infectious M.E./CFS, Byron Hyde, M.D., Alberto Marinacci, M.D. and Karl Von Hagen, M.D.
  • Chapter 47: Evidence for Organic Disturbance in the Post Viral Fatigue Syndrome: Neurophysiological Studies, Goran A. Jamal, M.D., Ph.D.

Section 15: M.E./CFS and Central Nervous System Injury[edit | edit source]

Section 16: Neuropsychological Changes in M.E./CFS[edit | edit source]

Section 17: Psychiatry in M.E./CFS[edit | edit source]

Section 18: Food Intolerance in M.E./CFS[edit | edit source]

Section 19: Immunology[edit | edit source]

Section 20: Blood Cell Changes[edit | edit source]

  • Chapter 62: Opioid-Mediated Monocyte Dysfunction in the CFS, Jesus Prieto, M.D. et al
  • Chapter 63: Paired, Age, Sex and Ethnically Matched Studies of Peripheral Blood Leucocyte Profiles in Early CFS, Michael Holmes, M.D. et al
  • Chapter 64: Working Towards a Diagnostic Aid in CFS: Analysis of Peripheral Blood Leucocyte Profiles by Radial Plot, John Cross, Ph.D et al
  • Chapter 65: The Role of Nondiscocytic Erythrocytes in the Pathogenesis of M.E./CFS, Len O. Simpson, Ph.D.
  • Chapter 66: Differentiation Between M.S. and M.E., E.J. Field, M.D., FRCP

Section 21: New Investigation Techniques[edit | edit source]

Section 22: Treatment[edit | edit source]

  • Chapter 69: Intravenous Immunoglobulin Therapy in Patients with CFS, Andrew Lloyd, M.D. et al
  • Chapter 70: Essential Fatty Acid Therapy for M.E., Michael D. Winther, M.D.
  • Chapter 71: Clinical Improvements Obtained with Ampligen in Patients with Severe CFS and Associated Encephalopathy, Daniel L. Peterson, M.D. et al
  • Chapter 72: Immunological Therapy with Transfer Factor, Andrew Lloyd, M.D. et al
  • Chapter 73: The Florence Nightingale Disease: A Multisystem Experiment of Nature: A 50 Patient Five Year Analysis, H. Hugh Fudenberg, M.D.
  • Chapter 74: The Role of Thymic Hormones in Viral Infections, Nathan Trainin, M.D. et al (See also Chapter 23: How I Diagnose..., Jay Goldstein, M.D.)

Section 23: Fibrositis / Fibromyalgia[edit | edit source]

  • Chapter 75: Fibrositis / Fibromyalgia Syndrome, I. Jon Russell, M.D., Ph.D

Section 24: Conclusions[edit | edit source]

Citation[edit | edit source]

Hyde, Byron, ed. (1992). The Nightingale Research Foundation Review of The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Jay Goldstein, Paul Levine. Ottawa, Ontario, Canada: Nightingale Research Foundation. ISBN 978-0969566205.

Links[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Publications". Nightingale Research Foundation. Retrieved September 21, 2019.